South Baylo University was established in 1977 in the City of Los Angeles as a post-secondary education institution. The University encompassed two schools: the School of Acupuncture and Oriental Medicine, and the School of Business Administration. The University moved to Garden Grove, California in the Spring 1982 as a nonprofit, public-benefit corporation and in the Fall 1994, moved again to its present location in Anaheim, California. Then in 1997, the schools separated and each became an independent school. As a free standing, accredited School of Acupuncture and Oriental Medicine, SBU continued to grow and has become one of the largest and prestigious AOM schools in the USA.

As a leader in Asian Medicine, SBU provides student centered education and training based upon the core value of HARMONY. Harmony of bodily Functions, Harmony of Mind and Body, and Harmony of Life and Nature are the very foundation of Acupuncture and Oriental Medicine.